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Possible Interaction: Gonadotropin-Releasing Hormone and Genistein

Research Papers that Mention the Interaction

Genistein , a selective inhibitor of protein tyrosine kinase, blocked PMA-induced increase in LHRH production, but not CD69 and IL-2R expression, suggesting that protein tyrosine phosphorylation events distal from PKC activation may play a role in regulating LHRH response.
Cellular immunology  •  1995  |  View Paper
GEN at 40 … significantly increased gonadotropin-releasing hormone (GnRH) mRNA expression in the hypothalamus, the serum estrogen (E2) level, and the laying rate, whereas 400 mg/kg of GEN … GnRH expression and the laying rate without significantly affecting E2, suggesting that high-dose GEN adversely affected the reproductive performance.
Front. Physiol.  •  2018  |  View Paper
Utilizing in vitro approaches, we observed that Genistein and BPA suppress inhibitory and activate stimulatory components of the GnRH network, while Dioxin exhibit an inhibitory effect at all regulatory hierarchical levels of the GnRH network.
Reproductive toxicology  •  2014  |  View Paper
GnRH neurones of juvenile mice injected with genistein in vivo showed an enhanced kisspeptin response compared to vehicle-injected controls.
Pre-incubation of GnRH neurones with 30 μm genistein enhanced kisspeptin-induced membrane depolarisation and firing.
Using a voltage clamp technique, we found that 30 μm genistein increased the frequency of synaptic current of GnRH neurones clamped at -60 mV in the presence of glutamate receptor blocker but not GABAA receptor blocker.
Journal of neuroendocrinology  •  2013  |  View Paper
Only the 10 micrograms dose of G was associated with increased pituitary response to GnRH , while progressive increases in exposure levels of G were associated with decreasing LH secretion.
Reproductive toxicology  •  1993  |  View Paper
Genistein , a selective inhibitor of tyrosine kinases, blocked GnRH and LH induction of rPGSi.
Endocrinology  •  1992  |  View Paper
Acute pretreatment of ovariectomized rats with genistein G ) alters gonadotropin-releasing hormone-(GnRH)-induced LH secretion in a fashion comparable to estradiol (E2).
Reproductive toxicology  •  1991  |  View Paper