Possible Interaction: Gonadotropin-Releasing Hormone and Genistein

“Utilizing in vitro approaches, we observed that Genistein and BPA suppress inhibitory and activate stimulatory components of the GnRH network, while Dioxin exhibit an inhibitory effect at all regulatory hierarchical levels of the GnRH network.”

“ GnRH neurones of juvenile mice injected with genistein in vivo showed an enhanced kisspeptin response compared to vehicle‐injected controls.”

“Pre‐incubation of GnRH neurones with 30 μm genistein enhanced kisspeptin‐induced membrane depolarisation and firing.”

“Using a voltage clamp technique, we found that 30 μm genistein increased the frequency of synaptic current of GnRH neurones clamped at −60 mV in the presence of glutamate receptor blocker but not GABAA receptor blocker.”

“ Genistein , a selective inhibitor of protein tyrosine kinase, blocked PMA-induced increase in LHRH production, but not CD69 and IL-2R expression, suggesting that protein tyrosine phosphorylation events distal from PKC activation may play a role in regulating LHRH response.”

“Immunohistochemical analysis revealed that genistein infusion affected the morphology of GnRH neurons evoking a visualization of long axons in the GnRH perikarya and visibly diminished IR GnRH stores in the median eminence.”

“In conclusion, our data show that genistein , a phytoestrogen, may effectively modulate GnRH and LH secretion in OVX ewes by acting directly on the CNS.”

“ Genistein , a selective inhibitor of tyrosine kinases, blocked GnRH and LH induction of rPGSi.”

“ GEN at 40 … significantly increased gonadotropin-releasing hormone (GnRH) mRNA expression in the hypothalamus, the serum estrogen (E2) level, and the laying rate, whereas 400 mg/kg of GEN … GnRH expression and the laying rate without significantly affecting E2, suggesting that high-dose GEN adversely affected the reproductive performance.”