Possible Interaction: Gonadotropin-Releasing Hormone and Calcium Supplement

“Application of GnRH induced a broad range of both electrophysiological responses and increases in the intracellular calcium concentration.”

“ GnRH is known to elevate intracellular calcium and activate the protein kinase C (PKC) pathway.”

“Treatment with GnRH induced a rapid increase in intracellular ionised calcium concentration in the NPC cells.”

“RESULTS Six months of go adotropin releasing hormone ag onist treatment reduced CA 12 5 and CA 19-9 levels.”

“Removal of the uterus or administration of GnRH significantly decreased peripheral concentrations of CA 125 to levels below those observed in normal women.”

“In a fifth, which was too small to allow inositol phospholipid turnover to be assessed, GnRH produced a rapid increase in mean intracellular calcium ion concentration.”

“Responses to a 10-microgram bolus GnRH dose revealed blunted (P less than 0.05) FSH release in CA and augmented (P less than 0.05) LH release in AA women.”

“In addition, we present a novel finding that GnRH suppresses pituitary adiponectin expression via the calcium and protein kinase A intracellular pathways in both cultured rat primary pituitary cells and the LβT2 gonadotrope cell line.”

“Nitric oxide and calcium also play a positive role on GnRH mRNA expression.”

“Removal of calcium resulted in potentiation of acute GnRH and PKC induction of LHbeta gene expression but prevented long-term repression by GnRH and reduced long-term repression by either calcium or 12-O-tetradecanoyl-phorbol-13-acetate (TPA).”