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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In conclusion, we have revealed for the first time that ACTH reduces the GnRH self-priming effect in vivo and delays the LH surge, at least partially by direct effects at the pituitary gland.”
“ Late ACTH did not affect the LH response after the first GnRH challenge (… > 0.05) but decreased maximum LH concentrations after the second GnRH to 35% (7.1+/-1.5 vs. 4.6+/-1.1 ng/ml; …+/-1.7 vs. 4.0+/-0.8 ng/ml; p = 0.05).”
Effect of adrenocorticotrophic hormone (ACTH1-24) on ovine pituitary gland responsiveness to exogenous pulsatile GnRH and oestradiol-induced LH release in vivo.“In Experiment 2, isolation/restraint reduced the LH response to GnRH in rams but not ewes and ACTH reduced the LH response to GnRH both in rams and ewes.”
“ GnRH increased fos proteins in subsets of ACTH and GH cells.”
“When the effect of this higher … oestradiol-priming was investigated, ACTH increased tonic LH …-priming effect of GnRH (1 x 10(-10) M GnRH; 945 +/- 274 vs. 922 +/- 323%; p > 0.05), and decreased (… LH released in response to KCl compared to the controls (1803 +/- 409 vs. 4302 +/- 1017%).”
“Studies in vitro with perifused ovine pituitaries showed that ACTH or corticotrophin releasing hormone markedly suppressed LH secretion in response to the second of two exposures to GnRH.”
“…,adrenocorticotrophic hormone (ACTH) … to GnRH , but only when GnRH was administered 3 h after ACTH, not after 0.5 h. This finding suggests that very early suppression … stressors is not mediated by ACTH action at the pituitary but that immediate activation of the sympathetic nervous system may be involved.”
“Furthermore, while Leu-Enkephalin can enhance the stimulating effect of LHRH, ACTH has a negative interaction with LHRH , when these two peptides are added together in incubation medium.”
“ ACTH infusion for 3 days reduced basal levels of serum T and the T response to GnRH , but did not alter basal levels of serum LH (immunoreactive) or the LH response to GnRH.”
“Injection of GnRH during ACTH treatment resulted in an LH surge and ovulation with development of corpora lutea.”
“In adrenalectomized rams LH release in response to LHRH was inhibited during ACTH treatment but was not affected in the absence of ACTH.”
“Therefore, ACTH reduced the responsiveness of the anterior pituitary gland to LHRH through a mechanism not involving the adrenal gland.”
“Treatment with ACTH resulted in significantly reduced LH values at all sample times after both injections of LH-RH.”
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