Possible Interaction: Glycyrrhizic Acid and Licorice

“The pharmacokinetics of glycyrrhizin have been described and show that its bioavailability is reduced when consumed as licorice ; this has hampered attempts to establish clear dose-effect levels in animals and humans.”

“Due to high GA content, coupled with its pronounced cytotoxic activity, the intake of liquorice root should be limited.”

“Among active components in GR , the beneficial effects of GR were attributable to presence of glycyrrhizic acid.”

“Taken together, our results indicate that GC may exert synergistic suppression of iNOS expression when coexisting with the other constituents contained in LE , and KO extract is a useful approach for determination of real pharmacological functions of natural compound in the phytochemical mixture.”

“Accordingly, the preventive effects of Gl radix may be attributable to GL , thus being related with the suppression of COX-2, IL-1alpha and TNF-alpha.”

“At least some of the factors in GE altering the bioavailability of GZ were identified.”

“The lipophilic components of GE reduced the gastric emptying rate and the absorption of GZ from the small intestine, while these effects were not observed in the hydrophilic components.”

“ Glycyrrhiza glabra L. has become an endangered medicinal plant due to the unabated extraction of glycyrrhizin.”

“There was significant positive correlation between glycyrrhizic acid and liquorice glycosides in short-term glycyrrhizic acid stimulation environment.”