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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glycyrrhetinic Acid
supplement:
Leucine
Research Papers that Mention the Interaction
“Results:… of 18β-glycyrrhetinic acid (18β-GA, 1–100 μmol/L) blocked both the peak current (INa,P) and late current (INa, L ) generated by WT and ΔKPQ Nav1.5 channels in a concentration-dependent manner, while 18α-glycyrrhetinic acid (18α-GA) at the same concentrations had no effects.”
18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels“In cultured atrium-derived myocytes (HL-1 cells), knocking-down of Cx43 or incubation with 30 mmol/L glycyrrhetinic acid significantly inhibited protein levels of Cav1.2 and Cav3.1, and the current density of ICa, L and ICa,T .”
Connexin 43 participates in atrial electrical remodeling through colocalization with calcium channels in atrial myocytes.
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