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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Glycyrrhetinic Acid
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“PI entry into the NPE was inhibited by calcium and by the connexin antagonist 18α-glycyrrhetinic acid (18-AGA).”
Connexins form functional hemichannels in porcine ciliary epithelium.“In these cell types, glycyrrhetinic acid in the concentration range of 20 to 100 microM caused an increase in [Ca2+]i and inhibited calcium increases induced by an antigen (mast cells), ATP, phenylephrine (hepatocytes) and thrombin (fibroblasts and endothelial cells).”
“In this report, we demonstrate that glycyrrhetic acid inhibits the Ca2+ -and phospholipid-dependent phosphotransferase activity of protein kinase C (PKC), the phorbol ester tumor promoter receptor.”
Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid.
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