Possible Interaction: Glycopeptides and Vancomycin

“The clinical use of glycopeptide antibiotic vancomycin is usually accompanied by nephrotoxicity, limiting its application and therapeutic efficiency.”

“The newer glycopeptides and linezolid decrease the total treatment costs compared with vancomycin , by reducing the length of stay or avoiding the hospitalization.”

“This case report describes a methicillin-resistant Staphylococcus aureus isolated repeatedly from the blood of a patient with community-acquired endocarditis who developed a four-fold increase in the minimal inhibitory concentration of vancomycin and daptomycin 7 months after his last exposure to glycopeptide antibiotics.”

“Resistance to glycopeptide antibiotics, especially vancomycin is of special concern.”

“Of 63 patients treated with vancomycin, only 14 (22.6%) patients had aimed trough levels of 15-20 mg/L. Vancomycin MIC ≥2 mg/L was detected in 28.2% and was associated with glycopeptide pretreatment (p 0.001).”

“INTRODUCTION As the susceptibility of staphylococcal strains to glycopeptides rises, it is becoming necessary to increase vancomycin dosages.”

“The only (blood) concentration of vancomycin measured during this episode does neither allow us to affirm, nor to exclude, that sub-inhibitory concentrations of vancomycin facilitated resistance to glycopeptides.”

“The clinical success of vancomycin in the treatment of multiresistant Gram-positive bacteria has stimulated further development of glycopeptide antibiotics and research of other Lipid II-binding compounds.”

“ST1-MRSA-I (1 out of 2 strains carrying ccr A2B2), ST8-MRSA-I (4 strains), ST15-… earliest STs among the MRSA strains in 1980.A temporal shift in the susceptibility levels to glycopeptides … vancomycin MIC of ≥ 2 mg/L increased from … glycopeptide MIC levels, reflecting a worldwide trend.”

“The inhibiting concentrations of the glycopeptides were 8 μg/ml for both vancomycin and teicoplanin.”