“According to the intrinsic chemicophysical properties …, hydrophilic antimicrobials (β-lactams, aminoglycosides, glycopeptides ) have to be considered at much higher risk of inter- … pharmacokinetic variations than lipophilic antimicrobials (macrolides, fluoroquinolones, tetracyclines, chloramphenicol, rifampicin [rifampin]) in critically ill patients, with significant frequent fluctuations … plasma concentrations that may require significant dosage adjustments.”