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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycopeptides
drug:
Daptomycin
Research Papers that Mention the Interaction
“Since glycopeptides and daptomycin have the same target site, there appears to be a risk of reduced susceptibility to both drugs after consecutive use.”
“Therefore, daptomycin should be used with caution for treatment of vancomycin-resistant isolates or after prior vancomycin ( glycopeptide ) therapy.”
Daptomycin: A Review 4 Years after First Approval“In our study, daptomycin resistance arose during glycopeptide therapy.”
“We review the observed effects of reduced glycopeptide susceptibility on the activities of daptomycin in S aureus in vitro and in vivo.”
“The prolonged glycopeptide treatment probably not only selected vancomycin-intermediate MRSA but also weakened the bactericidal activity of daptomycin.”
“5 Since extended use of daptomycin resulted in elevated MIC values of these glycopeptides (vancomycin and daptomycin), it is possible that exposure to daptomycin, like vancomycin, may cause thickening of the bacterial cell wall, thus decreasing susceptibility to a number of peptides.”
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