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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycocyamine
drug:
Simvastatin
Research Papers that Mention the Interaction
“Sasani et al. report that patients treated with the statin simvastatin had a lower amount of both homoarginine and guanidinoacetic acid in their blood, a finding consistent with a reduced expression of the enzyme l-Arginine: glycine amidinotransferase (AGAT, also sometimes called GATM for “glycine amidinotransferase, mitochondrial”).”
Presence of guanidinoacetate may compensate creatine absence and account for less statin-induced muscle damage in GAMT-deficient compared to AGAT-deficient mice
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