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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“A significant increase in the IC50 value of valproate cytotoxicity after addition of 12 mmol/l glycine was found.”
“Cells treated with valproate in combination with 12 mmol/l glycine showed less histomorphological deformation of the nucleus and improved cell adherence.”
Glycine affects valproate hepatotoxicity.“Further in vitro studies on intact rat liver mitochondria and the sol‐ubilized glycine cleavage system showed that valproic acid and valproyl‐CoA significantly inhibited the glycine cleavage enzyme complex.”
“Plasma glycine levels were significantly raised (p <0.001) in those epileptics who were on valproic acid (monodrug therapy), in comparison with those on multiple anti-epileptic agents.”
“There were significant positive correlations between glycine levels and trough valproic acid levels (r = 0.830), duration of treatment (r = 0.525) and frequency of seizures (r = 0.326).”
“ Valproate should be avoided because it disturbs the balance between branched and non-branched aminoacids [3] and elevates cerebral glycine [4].”
“ Valproate sodium interferes with the glycine cleavage enzyme synthesis in the mitochondria, hence increasing glycine levels.”
“ Valproate administration increases the level of the inhibitory transmitter, glycine , in the urine and plasma of patients and experimental animals.”
Paracetamol prevents hyperglycinemia in vervet monkeys treated with valproate“The increase of either gamma-aminobutyric acid/taurine or glycine releases during the seizure period could be inhibited by the application of valproate likewise.”
“This study evaluated a possible mechanism by which glycine potentiates the activity of diazepam (DZP) and valproic acid (VAL) against the clonic seizures induced by pentylenetetrazol (PTZ) in rats.”
“Because the mechanism of toxicity of acetaminophen probably is different from that of VPA, a nonspecific cytoprotective effect may contribute to glycine antagonism of valproate toxicity.”
“ Glycine also partially antagonized inhibition of fatty acid β‐oxidation by VPA , as estimated by the generation of acid‐soluble products from [14C]palmitic acid.”
“These results are consistent with the hypothesis that glycine prevents VPA toxicity by removing acyl‐CoA esters, which accumulate during VPA exposure and interfere with fatty acid p‐oxidation.”
“ Valproate caused a doseependent increase in leakage of lactic acid dehy‐drogenase (LDH), and glycine prevented this toxic response.”
“In contrast to its effects on felbamate, glycine either potentiated or had no effect on the anticonvulsant actions of phenytoin, valproate , carbamazepine and phenobarbital on electroshock seizures in mice.”
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