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Last Updated: 2 years ago

Possible Interaction: Glycine and Valine

supplement:

Glycine

supplement:

Valine

Research Papers that Mention the Interaction

As neither of the branched chain amino acid transaminases proved to be inhibited by glycine, inhibition by glycine of the uptake of valine by the tissues became likely.
Glycine was found to … competitive inhibitor of valine uptake, with a Ki of 4.9 mM. It is concluded that the tendency to a decreased rate of valine disappearance … blood in non-ketotic hyperglycinemia could be due to an inhibition of valine uptake by the high plasma glycine concentration.
Helvetica paediatrica acta  •  1975  |  View Paper
HD causes a significant decrease in CSF/P ratios of branched chain AA (BCAA) and a significant increase in CSF Glycine/Valine ratio, suggesting an augmented brain uptake of Glycine at detriment of Valine.
The International journal of artificial organs  •  1984  |  View Paper
Alpha-aminoisobutyric acid, valine , and thioproline are also shown to inhibit glycine uptake.
Metabolism: clinical and experimental  •  1979  |  View Paper
Replacing a glycine with valine in the turn between the last two β-strands (Gly121Val) slows the folding process by more than three orders of magnitude.
Proceedings of the National Academy of Sciences  •  2007  |  View Paper
In addition, glutamine (Q387), valine (V666), and serine (S669) substitutions were found to reduce glycine efficacy.
Neuron  •  1994  |  View Paper
We show here that a single exchange of glycine 450 with a valine residue, or an internal deletion of amino acids 444-452, strongly interferes with the normal assembly of IFs under in vitro conditions.
Journal of cell science  •  1993  |  View Paper
Glycine, D- or L-serine, L-threonine, L-methionine, L-alanine, and L-valine all individually protected against the inactivation of glycine , L-serine, L-threonine, L-methionine, L-alanine, L-valine, L-proline, and beta-alanine transport, while L-proline, beta-alanine,
Biochemistry  •  1977  |  View Paper
Substitution of phenylalanine for valine increased, and substitution of lysine or glycine for valine considerably decreased the rate of phosphorylation.
Biochemical and biophysical research communications  •  1976  |  View Paper
Glycine and valine are partially competitive inhibitors and homoarginine, alanine and methionine are completely competitive.
The Journal of protozoology  •  1971  |  View Paper
Substitution of glycine 88 with valine (Gly88Val) destabilizes staphylococcal nuclease by 1.0 kcal mole-1 and reduces its sensitivity to the denaturant guanidine hydrochloride, a phenomenon which may indicate an increase in residual structure in the denatured state.
Structure  •  1993  |  View Paper