Possible Interaction: Glycine and Threonine

“SummaryPreclinical data indicate that the administration of the amino acid L-threonine increases glycine levels in rat spinal cord.”

“The presented data indicate that increasing the threonine in plasma leads to increasing brain glycine and thereby affects the neurotransmitter balance in the brain.”

“There was a positive significant correlation between threonine and glycine concentrations in the cortex (r = 0.673, p < 0.01), and the brain stem (r = 0.575, p < 0.01), whereas the glycine concentration decreased with increasing threonine intakes in the liver and muscle.”

“Threonine conversion to glycine tended to be higher on + Thr and +P-Thr vs. control (3.5, 3.4, and 1.6 micromol x kg(-1) x h(-1), SD 1.3, P = 0.06).”

“The significant increase of the glycine and of glutaminic acid with threonine levels (36.4% and 62.2%, respectively) and significant decrease in the level of leucine with isoleucine (16.5%) has been stated in patients if compare with the control group.”

“At d 35, an interaction (P ≤ 0.01) … observed between the Gly+Ser and dig Thr levels for G:F. Glycine supplementation resulted in a linear increase (P < 0.05) in BW gain, G:F, intestinal mucin secretion, apparent digestibility of fat, and AME values of the experimental diets.”

“Further analysis indicated that glycine uptake was independent of luminal pH and proline, but a component of uptake was significantly impaired by 100-fold excesses of threonine or asparagine.”

“Added glycine (0.3 mM) marginally suppressed threonine oxidation.”

“Whole-body glycine , proline, serine and cystine concentrations decreased (P < 0.05) as Thr was increased in the diet.”

“Simultaneously there is a significant increase of glycine and threonine in plasma.”

“In intact and freeze-thawed mitochondria, the ratio of glycine to aminoacetone formed was markedly sensitive to the concentration of L-threonine , glycine being the major product at low L-threonine concentrations.”