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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glycine
drug:
Tetrahydrofolate
Research Papers that Mention the Interaction
“However, catalytic activity was greatly decreased for serine and allothreonine cleavage and for the solvent alpha-proton exchange of glycine in the presence of tetrahydrofolate.”
Role of tyrosine 65 in the mechanism of serine hydroxymethyltransferase.“Both enzymes catalysed the removal of the pro-S hydrogen atom of glycine , which was greatly enhanced by the presence of tetrahydrofolate.”
Mechanistic, inhibitory and stereochemical studies on cytoplasmic and mitochondrial serine transhydorxymethylases.“With glycine , removal of tetrahydrofolate led to a large decrease in the stereospecificity of the exchange reaction but did not affect the exchange rates of the alpha-protons of any of the larger amino acids studied.”
A substrate-induced change in the stereospecificity of the serine-hydroxymethyltransferase-catalysed exchange of the alpha-protons of amino acids--evidence for a second catalytic site.“In the absence of tetrahydrofolate this decrease in stereospecificity was largely due to the decrease … the second order exchange rate of the pro-2S proton, while in the presence of tetrahydrofolate the large increase in the second order … rate of the pro-2R proton of glycine made a … contribution.”
“However, the data do support the interpretation that the ability of tetrahydrofolate to increase by 3 orders of magnitude the enzyme-catalyzed rate of exchange of the alpha-hydrogen of glycine with protons of the solvent is attributable to an increased rate of formation of the 495-nm complex.”
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