Possible Interaction: Glycine and Taurine

“However, introduction of glycine at this position decreases the IC50 for taurine by approximately 8-fold (IC50 approximately 0.20 mM).”

“Alternative-substrate-inhibition studies with glycine and taurine in soluble fractions from guinea-pig and rabbit liver revealed that glycine and taurine were mutually inhibitory.”

“… taurine supplementation significantly ….001), plasma glycine (WMD:-106.71; P = 0.033), alanine (WMD:-229.30; P = 0.002), leucine (WMD:-64.76; P < 0.001), tyrosine (WMD:-…:-52.16; P < 0.001), proline (WMD: -84.29; P = 0.033), and asparagine-glutamine (WMD:-356.30; P < 0.001).”

“Treatment with taurine and glycine conjugates of lithocholic and deoxycholic acids stimulated reversible activation of the p44/42 MAP kinase signaling cascade and proliferation of H508 cells.”

“ Taurine was also converted to a weak partial agonist and antagonized the actions of glycine , consistent with changes in its channel gating efficacy.”

“Additionally, the binding of the glycinergic agonists beta-alanine and taurine to mutated GlyRs does not initiate a chloride current, but instead competitively antagonizes currents activated by glycine.”

“A large difference in bile acid composition between glycine and taurine conjugates was found to be present.”

“In rat hippocampal slices, the application of several amino acids (l- and d-alanine, l-glutamine, β-guanidinopropionic acid, glycine , l-histidine, l- and d-serine, sarcosine, l- and d-threonine) imitated the synaptic potentiation induced by taurine.”

“These data indicate that a high concentration of taurine in vitro mediates its effects through both glycine and GABAA receptors, and suggests that taurine, in addition to GABA, inhibits neuronal activity during anoxia in the turtle cortex.”

“The taurine effect can be partially mimicked by glycine.”