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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glycine
drug:
Substance P
Research Papers that Mention the Interaction
“ Synthetic substance P (SP) raises glycine levels both in the brain and in the spinal cord.”
Mechanism of action of substance P“Because SP inhibits the ATP stimulation of glycine release , SP may play a significant role in hyperalgesia or chronic pain.”
Substance P Abolishes the Facilitatory Effect of ATP on Spontaneous Glycine Release in Neurons of the Trigeminal Nucleus Pars Caudalis“ Substance P (10 microM) evoked a significant increase in the release of aspartate, glutamate, GABA, glycine and taurine.”
“In addition, substance P also increased the concentrations of the inhibitory amino acids glycine and taurine.”
“Intrathecal administration of glycine (400 micrograms but not 66 micrograms) significantly decreased the effect of substance P on this behavior.”
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