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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glycine
drug:
Strychnine
Research Papers that Mention the Interaction
“Radioligand binding assays showed a 90‐ to 1365‐fold reduction in the ability of glycine to displace [3H]strychnine from its binding site on the mutant receptors.”
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia.“Strychnine reversibly blocks the action of inhibitory transmitters, glycine and β-alanine, but is without effect on the … action of GABA.These results indicate that glycine may be a major spinal inhibitory transmitter, in which case strychnine affects spinal postsynaptic inhibition … limiting the action of glycine upon subsynaptic … receptors.”
The hyperpolarization of spinal motoneurones by glycine and related amino acids“The addition of glycine or taurine (0.1 µm–1 mm) produced a dose‐dependent inhibition of [3H]strychnine binding.”
“After bath application ofeither an excitatory amino acid (AP-5 … CNQX) and a nicotinic cholinergic (DHβE or mecamylamine) antagonist,or glycine and GABA receptor (bicuculline, 2-hydroxysaclofen, and strychnine) antagonists, spontaneous activity was blocked for a period (30–90 min) but then reappeared in the presence of the drugs.”
“The dissociation of the antagonist [3H]strychnine elicited by dilution was preferentially accelerated by glycine.”
“ Glycine activated a Cl- conductance that was blocked by strychnine acting as a mixed inhibitor, effecting both Imax and Kd.”
“The dissociation constant (KD) of [3H]strychnine binding to the purified glycine receptor was 9.3 +/- 0.6 nM. The glycine receptor agonists glycine , beta-alanine, and taurine inhibited the binding of [3H]strychnine to the purified receptor.”
“Addition of glycine to the strychninised membrane led to a decrease in fluorescence indicating same receptor loci.”
“The incorporation of [3H]strychnine into these membranes could be inhibited by glycine.”
“In two cats, intravenous strychnine (1‐2 mg/kg) had no effect on the ACh‐evoked inhibition, while greatly reducing the sensitivity of the cell under study to glycine.”
“ Iontophoretic strychnine only rarely affected the inhibition evoked by ACh, while readily blocking the inhibition evoked on the same cell by an equipotent dose of glycine.”
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