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“Enhancement curves by glycine in the presence of increasing concentrations of the glycine antagonist 7-chlorokynurenate revealed that spermine markedly increased the affinity of glycine but not that of 7-chlorokynurenate, and that glycine was also required for [3H]dizocilpine binding in the presence of spermine.”
European journal of pharmacology • 1994 | View Paper
“ Spermine increased the affinity of glycine site agonists in displacing [3H]L-689,560 binding, with no effect on inhibition by partial agonists or antagonists, suggesting that spermine promotes an 'agonist-preferring' state.”
European journal of pharmacology • 1994 | View Paper
“Dose‐response analysis for the glycine‐sensitive activation of NMDA receptors at +60 mV revealed a 3.5‐fold increase in apparent affinity for glycine in the presence of 1 mM spermine.”