Possible Interaction: Glycine and Serotonin

“Together our results suggest that 5-HT inhibits the release of glycine by activation of 5-HT1B/D receptors.”

“The data obtained show that 5-HT regulates the probability of glutamate and glycine release from the presynaptic terminals ending at frog spinal motoneurons.”

“Intrathecal injection of 5-HT decreased the level of glycine in the lumbosacral cord.”

“the interactions between 5-HT and Gly might modulate the transmission of nociceptive information through the spinal cord.”

“Starting at E18, 5-HT also induced high-frequency fast-rising potentials that were blocked by antagonists of glutamate, gamma-aminobutyric acid, and glycine.”

“Taken together, these data indicate that 5-HT acts presynaptically to increase the probability of evoked and spontaneous release of glycine.”

“ Glycine strongly antagonized this inhibitory effect of 5-HT , and 5-HT reduced opening of NMDA-gated single channels recorded from the outside-out membrane patch.”

“Although most examples of modulation of synaptic transmission have been obtained from excitatory rather than from inhibitory connections, serotonin (5HT) is now shown to cause a presynaptic facilitation of release of the inhibitory neurotransmitter glycine.”

“A number of substances, including glycine , epinephrine, and acetyl-choline, caused a significant release of serotonin , with acetylcholine having the greatest effect.”

“The interaction between 5-HT and glycine appears to have a significant role in modulating the transmission of the nociceptive pathway.”