Possible Interaction: Glycine and Serine

“Finally, the inhibition of biosynthesis of either serine ( Psat1 -KO) or fatty acid ( Fasn -KO) is compensated for by uptake of circulating nutrients, and dietary restriction of both serine and glycine or fatty acids synergistically suppresses tumourigenesis.”

“Either NMDA or Gly alone significantly increased Ca2+ accumulation in cultured chondrocytes, whereas D‐Ser significantly prevented Ca2+ accumulation by Gly , but not by NMDA.”

“Gly alone also significantly increased gene transactivation by the introduction of runt‐related transcription factor‐2 (Runx2) in COS7 cells transfected with NR1 and NR3A subunits, while D‐Ser significantly prevented the increase by Gly without affecting the promoter activity of Runx2.”

“Evidence is provided that serine in place of glycine at one or more positions causes a significant increase in specificity with factor XIIIa, but not with liver enzyme.”

“An increased excretion of urinary beta-hydroxyaspartic acid was observed in cats when serine or thiamine was administered with glycine.”

“In similarity to recent studies, the authors demonstrated that upon serine and glycine starvation tumour progression was significantly decreased.”

“ D‐serine and glycine are coagonists of N‐methyl‐D‐aspartate (NMDA) receptor subunit GRIN1.”

“Interestingly, the ratio of l-serine to glycine in patients was significantly higher than that of healthy controls (p<0.001).”

“Although serine and glycine can be interconverted and either might be used for nucleotide synthesis and one-carbon metabolism, we show that exogenous glycine cannot replace serine to support cancer cell proliferation.”

“Conversely, glycine and D‐serine , co‐agonists of NMDA receptors, enhanced the GABA release.”

“We report on two sisters with phenotypic heterogeneity and a favourable response to combined serine and glycine supplementation.”