Possible Interaction: Glycine and Sarcosine

“However, in cerebellum synaptosomes, the maximal inhibition produced by NFPS and sarcosine was only half that produced by glycine.”

“In cortex synaptosomes, NFPS and sarcosine produced the same maximal inhibition of uptake as glycine itself.”

“ Sarcosine , glycine transporter inhibitor, increases glycine levels around NMDA receptor, improving primary negative symptoms of schizophrenia.”

“Added glycine and sarcosine also reduce the distribution ratio.”

“In Experiment 5, the injection of sarcosine enhanced CSF levels of glycine and serine in rat brain.”

“Furthermore, these motor bursts were facilitated by the glycine uptake blocker sarcosine.”

“ Sarcosine , a natural amino acid found in muscles and other body tissues, is an endogenous glycine transporter type 1 inhibitor that increases the glycine concentration, resulting in an indirect potentiation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors.”

“We examined this possibility using whole-cell recordings from cultured embryonic mouse hippocampal neurons and found that sarcosine evoked a dose-dependent, strychnine sensitive, Cl(-) current that cross-inhibited glycine currents.”

“GlyT1 inhibitors ALX 5407 and sarcosine reduced total glycine uptake to 80% whereas the specific GlyT2 inhibitor Org 25543 had no effect.”

“Depression of both the frequency and amplitude of respiratory bursts was induced by blockades of GABA and glycine uptake using, respectively, nipecotic acid and sarcosine.”

“Although glycine uptake was insensitive to staurosporine and phorbol ester, it was reduced 40-50% by sarcosine and ALX5407.”