Possible Interaction: Glycine and Salicylic Acid

“ SA was eliminated to about 60% by conjugation with glycine and therefore SUA was a dominant metabolite in urine.”

“In both an inward and outward direction, the transport rates of SA and GA were rapid, while those of SAU and GAU were lower by conjugating glycine.”

“This is consistent with other evidence showing that the conjugation of benzoate and salicylate with glycine in man involves different rate-limiting steps.”

“The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine , resulting in the formation of hippuric acid and salicyluric acid, respectively.”

“aspirin equivalent, conjugation of salicylic acid with glycine reached a maximum rate and thus proceeded by zero-order kinetics.”

“Following poly rI:rC administration to DBA/2 mice, the metabolic conjugation of salicylic acid with glycine was significantly increased, glucuronidation was little changed and there was an approximately 10-fold reduction in the excretion of the oxidation product, gentisic acid.”

“Here, we show that although 10 to 100 microM … the absence of a pathogen, physiological concentrations of SA markedly enhanced the induction of defense … strain of Pseudomonas syringae pv glycinea , with optimal effects being at approximately 50 microM. SA also … 2A inhibitor cantharidin in the absence of a pathogen.”

“ Glycine is the only compound so far found which potentiated the action of salicylic acid.”