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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
supplement:
S-Adenosylmethionine
Research Papers that Mention the Interaction
“Studies with cell-free extracts demonstrated that the glycine cleavage enzyme is inhibited by 45% by L-methionine, L-homocysteine, SAM or SAH.”
Disruption of thymidylate synthesis and glycine-serine interconversion by L-methionine and L-homocystine in Raji cells.“In mammalian liver it reduces S-adenosylmethionine levels by using it to methylate glycine , producing N-methylglycine (sarcosine) and S-adenosylhomocysteine.”
Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate.“We noticed that the in vivo concentration of S-adenosyl methionine increased in parallel with the addition of glycine , while the addition of methione in the fermentation medium significantly decreased the productivity of apramycin.”
Glycine origin of the methyl substituent on C7′-N of octodiose for the biosynthesis of apramycin
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