Possible Interaction: Glycine and Propofol

“Quantitative analysis of the agonist responses of the isofunctionally substituted α1(R271K) mutant GlyR revealed that saturating concentrations of PRO decreased the EC50 values of both glycine and the partial agonist β-alanine by >10-fold, with relative efficacies increasing by 4- and 16-fold, respectively.”

“5) Propofol and etomidate potentiate the current response to bath applied glycine (50 microM) by 200 and 10%, respectively, at clinically relevant concentrations. (”

“Recent investigations show that propofol potentiates the inhibitory transmitters glycine and γ-aminobutyric acid (GABA) which would enhance spinal inhibition during anaesthesia.”

“Conclusion: Propofol inhibits GLIC by stabilizing a distinct closed channel state.”

“Desflurane, halothane, isoflurane, sevoflurane, and propofol inhibited currents through GLIC at and below concentrations used clinically.”

“In addition, propofol markedly increased the currents elicited by glycine and GABA of hypothalamic neurons.”

“Sympathetic and cardiovascular responses to blocking neurons in the pontine reticular formation by microinjection of glycine were depressed by propofol.”

“ Glycine concentrations also were lower in the propofol group when compared to the isoflurane and pentobarbital groups.”

“ Propofol attenuated glycine increases in a manner similar to that of hypothermia but did not attenuate ischemia-induced glutamate increases.”

“Sympathetic and cardiovascular responses to blocking neurons in the ventrolateral medulla with microinjection of glycine were depressed by propofol.”

“Under identical ionic conditions, GABA (1 μm) activated single channels with mean chord conductances of 33, 16 and 10 pS. 7 Bath applied propofol (0.84–16.8 μm) dose‐dependently potentiated strychnine‐sensitive currents evoked by glycine (100 μm) in murine spinal neurones.”