Possible Interaction: Glycine and Potassium

“ GLY did not block the isoproterenol-induced increase in [Ca2+]c, but did prevent the potassium chloride-induced increase in [Ca2+]c in cardiomyocytes.”

“In the synaptosomal fraction, 68.5 mM potassium significantly stimulated the efflux of GABA and glycine by a calcium-dependent mechanism.”

“Furthermore, potassium (25 mM) and LPS depolarized the Kupffer cell plasma membrane, whereas glycine caused hyperpolarization and prevented depolarization due to potassium and LPS.”

“ Glycine also attenuated the weight loss, polyuria, increased fractional excretion of sodium and potassium , decreased urinary osmolality, and renal glycosuria observed in control, saline-treated rats after cisplatin, while substantially decreasing the percentage of S3 tubules with evident morphological injury.”

“Significant inhibition of pupil response to light but not to the dark was apparent following systemically administered glycine resulting in plasma levels over 5000 mumol/L. Inhibition of pupil response was paralleled by behavioral indices of visual impairment but not by changes in plasma sodium, potassium , chloride or osmolality.”

“In both CN and CX, potassium (5-55 mM) produced a concentration-dependent increase in the release of Asp, Glu, Gly , and GABA in the presence of extracellular Ca2+.”

“Elevated potassium concentration in the medium stimulated the release of glycine and taurine.”

“Values for K t , the concentration at which half-maximal transport is observed, diminished with increasing length of side chain for glycine , l-alanine, l-valine, and l-leucine.”

“We found that both influx and efflux of potassium increased when the cells were maintaining established gradients for glycine ; both fluxes also increased during the accumulation of glycine.”

“Analysis of the steady-state kinetics revealed that glycine in the reaction mixture increases the K m and k cat values of the enzyme.”