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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
drug:
Phenobarbital
Research Papers that Mention the Interaction
“In seizures caused by pentylenetetrazol, glycine potentiated the anticonvulsant effect of phenobarbital only slightly; in combination with dilantin, which was ineffective by itself, it did not have an effect.”
Glycine potentiates the action of some anticonvulsant drugs in some seizure models“significantly antagonized the potentiation of anticonvulsant activity induced by glycine co-administered with either phenobarbital or phenytoin.”
“Administered together with the anticonvulsants, glycine significantly enhanced the anticonvulsant potency of phenobarbital and carbamazepine.”
“ Glycine potentiated the effects of phenobarbital on the cortical afterdischarge but not the severity of the seizures.”
“However, phenobarbital administration to young weanling animals significantly increased 14CO excretion from glycine-2 -14C, but did not result in a change in the activity of hepatic heme oxygenase.”
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