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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Substitution of the two deduced contact …, Leu-73 and His-75, with Gly resulted … papain and cathepsins H and B. These losses indicated that the two residues together contribute 20-30% of … of cystatin B to these enzymes and that Leu-73 is responsible for most of this contribution.”
Importance of the second binding loop and the C-terminal end of cystatin B (stefin B) for inhibition of cysteine proteinases.“Substitution of this residue by Gly markedly altered the spectroscopic changes accompanying papain binding and reduced the affinity for papain, actinidin, and cathepsins B and H by 300-900-fold.”
“… Gly‐9 and Ala‐… for papain than the two isoelectric forms (pI=6.5 and 5.6) of the full‐length inhibitor (K i=6 pM and 7 … Leu‐7 (K i=6 pM), indicating the outstanding importance of one or two residues preceding conserved Gly‐9 for binding.”
Mechanism of inhibition of papain by chicken egg white cystatin
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