Possible Interaction: Glycine and Nitric Oxide

“Glycine and proline only marginally stimulated the IL-8 production by IL-1β-stimulated gingival fibroblast, whereas glycine dose-dependently inhibited the nitric oxide production by lipopolysaccharide-stimulated mouse macrophage-like RAW264.7 cells.”

“Other molecules, such as the dietary supplement glycine propionyl-L-carnitine (GPLC), have also been suggested to increase levels of NO , although the physiological mechanisms remain to be elucidated.”

“BACKGROUND: The amino acid glycine modulates immunological response and enhances the production of endothelial derived nitric oxide (EDNO) factor.”

“Conclusions Our results indicate that NO induces release of aspartate, glutamate, glycine and GABA in cortical neurons and that this release is inhibited by ODQ, an inhibitor of soluble guanylate cyclase.”

“Taken together, these findings support the hypothesis that GLY and GABA interact in the regulation of the NO/cGMP signaling pathway, where GLY primarily inhibits NO production and GABA has a greater effect on cGMP production.”

“In general, we show that NO stimulated GABA release and inhibited glycine release.”

“ NO promoted glycine uptake and inhibited its release, and this inhibition of glycine release was influenced by GABAergic modulation.”

“These findings indicate that NO modulates the levels of the inhibitory transmitters GABA and glycine through several specific biochemical mechanisms in different retinal cell types and layers.”

“We have explored the possible modulation by nitric oxide NO ) of inhibitory synaptic transmission mediated by either glycine or GABA during episodes of rhythmic fictive swimming in postembryonicXenopus laevis tadpoles.”

“The increase in plasma TNFalpha and nitric oxide NO ) was also blunted by glycine feeding.”

“We suggest that NO , apart from its well known function in gap junction regulation, can also modulate the release of both GABA and glycine in the turtle retina.”

“The result suggests that NO released endogenously from SPNs may act as a retrograde messenger molecule to enhance the release of glycine or a related substance, possibly via a cGMP‐dependent mechanism.”