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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
drug:
Nitrendipine
Research Papers that Mention the Interaction
“In addition to their blocking effects, nitrendipine and nicardipine potentiated the peak responses to low glycine concentrations.”
Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons“These data suggest that glycine may facilitate opening of the voltage‐dependent calcium channels activated by N‐methyl‐d‐aspartate and that this facilitation is blocked by the antagonist nitrendipine.”
“As measured with the calcium-… probe indo-1, nitrendipine (0.1-10 microM) attenuated inward calcium flux … by bath application of NMDA (100 microM) and glycine (100 microM), in a concentration-dependent (IC50, 0.56 +/- 0.21 microM; 95% confidence interval, 0.19-1.3 microM) and reversible manner.”
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