Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Glycine and Morphine

supplement:

Glycine

Research Papers that Mention the Interaction

The abstinence syndrome to morphine , induced by naloxone administration to primed mice, was reduced by single doses of glycine or beta-alanine.
The Journal of pharmacy and pharmacology  •  1980  |  View Paper
These results indicate the elevated D-serine level following the chronic morphine treatment could at least in part be involved in the activation of NMDA receptors via the glycine site.
Journal of pharmacological sciences  •  2008  |  View Paper
administration of 10 mg/kg morphine increased the glutamate level and decreased GABA and glycine levels in cortex.
Biomeditsinskaia khimiia  •  2005  |  View Paper
Electrophoretically administered morphine and codeine, but not meperidine, blocked the inhibitory effect of glycine on spinal neurones, without reducing the effectiveness of GABA.
Agents and Actions  •  2005  |  View Paper
Within the same sites, morphine increased the synthesis of glycine.
Neurochemical Research  •  2004  |  View Paper
Glycine inhibited the development of postsynaptic dopamine receptor supersensitivity induced by repeated administration of morphine.
Archives of pharmacal research  •  2003  |  View Paper
morphine … glycine , D(−)‐2‐amino‐5‐phosphonovaleric acid (D‐AP5, an N‐methyl‐D‐aspartate (NMDA) receptor antagonist), γ‐D‐glutamylaminomethyl sulphonic acid (GAMS, a non‐… soluble guanylate cyclase inhibitor), but were not affected by muscimol (a γ‐aminobutyric acidA (GABAA) receptor agonist) and baclofen (a GABAB receptor agonist).
British journal of pharmacology  •  1997  |  View Paper
The analgesic effect of morphine was antagonized in mice by intracerebroventricular pretreatment with taurine, gamma-aminobutyric acid (GABA) or glycine and was potentiated by ethylene glycol tetra-acetic acid (EGTA) but not altered by L-glutamate or L-aspartate.
European journal of pharmacology  •  1981  |  View Paper
Our main finding is that the opiate agonists, morphine and levorphanol (5-100 microM), consistently depressed the responses evoked by the putative inhibitory amino acid neurotransmitters glycine and beta-alanine but not GABA.
Brain Research  •  1981  |  View Paper
Only morphine specifically reduced the depressant effect of glycine without affecting that of γ-aminobutyric acid.
European journal of pharmacology  •  1974  |  View Paper
Show More