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Discover Supplement-Drug Interactions

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Last Updated: a month ago

Possible Interaction: Glycine and Methotrexate

supplement:

Glycine

Research Papers that Mention the Interaction

Twins have multiple mutations: a CC mutation of SNP 1298A>C in methylenetetrahydrofolate reductase (MTHFR) gene, CC mutations of … the adenosine receptor gene ADORA2A (rs3761422_4217241T>C, rs2267076_4221164T>C, rs2236624_4226593T>C), and a heterozygous genotype in SNPs ATIC_rs2372536_347C G , MTHFD1_rs2236225_1958G>A. These mutations are … predict a worse outcome of MTX ….
International journal of immunopathology and pharmacology  •  2016  |  View Paper
776C G influences both neurotoxicity and efficacy of MTX in the Bonn PCNSL protocol.
British Journal of Cancer  •  2012  |  View Paper
Thymidine, glycine , and adenosine (GAT) prevent methotrexate toxicity only if maintained in the incubation medium.
Advances in experimental medicine and biology  •  1983  |  View Paper
Within 5 min MTX inhibited the incorporation of isotopically-labeled deoxyuridine, hypoxanthine and glycine into DNA, although thymidine incorporation continued normally for more than 90 min before becoming inhibited.
European journal of cancer  •  1975  |  View Paper
It has been demonstrated that formate and glycine are effective precursors of ATP adenine and that A-methopterin inhibits the synthesis of this nucleotide.
Cancer research  •  1952  |  View Paper