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Discover Supplement-Drug Interactions
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Last Updated: a month ago
supplement:
Glycine
drug:
Methotrexate
Research Papers that Mention the Interaction
“Twins have multiple mutations: a CC mutation of SNP 1298A>C in methylenetetrahydrofolate reductase (MTHFR) gene, CC mutations of … the adenosine receptor gene ADORA2A (rs3761422_4217241T>C, rs2267076_4221164T>C, rs2236624_4226593T>C), and a heterozygous genotype in SNPs ATIC_rs2372536_347C G , MTHFD1_rs2236225_1958G>A. These mutations are … predict a worse outcome of MTX ….”
Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins.“776C G influences both neurotoxicity and efficacy of MTX in the Bonn PCNSL protocol.”
“Thymidine, glycine , and adenosine (GAT) prevent methotrexate toxicity only if maintained in the incubation medium.”
“Within 5 min MTX inhibited the incorporation of isotopically-labeled deoxyuridine, hypoxanthine and glycine into DNA, although thymidine incorporation continued normally for more than 90 min before becoming inhibited.”
“It has been demonstrated that formate and glycine are effective precursors of ATP adenine and that A-methopterin inhibits the synthesis of this nucleotide.”
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