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Discover Supplement-Drug Interactions
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Last Updated: 6 months ago
supplement:
Glycine
drug:
Methotrexate
Research Papers that Mention the Interaction
“Thymidine, glycine , and adenosine (GAT) prevent methotrexate toxicity only if maintained in the incubation medium.”
Methotrexate polyglutamates in cultured human cells.“Within 5 min MTX inhibited the incorporation of isotopically-labeled deoxyuridine, hypoxanthine and glycine into DNA, although thymidine incorporation continued normally for more than 90 min before becoming inhibited.”
“It has been demonstrated that formate and glycine are effective precursors of ATP adenine and that A-methopterin inhibits the synthesis of this nucleotide.”
“Furthermore, MTX inhibited formate generation from mitochondria glycine cleavage system (GCS) both in vitro and in vivo.”
Folinate Supplementation Ameliorates Methotrexate Induced Mitochondrial Formate Depletion In Vitro and In Vivo
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