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Discover Supplement-Drug Interactions
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Last Updated: 4 months ago
supplement:
Glycine
drug:
Methotrexate
Research Papers that Mention the Interaction
“Twins have multiple mutations: a CC mutation of SNP 1298A>C in methylenetetrahydrofolate reductase (MTHFR) gene, CC mutations of … the adenosine receptor gene ADORA2A (rs3761422_4217241T>C, rs2267076_4221164T>C, rs2236624_4226593T>C), and a heterozygous genotype in SNPs ATIC_rs2372536_347C G , MTHFD1_rs2236225_1958G>A. These mutations are … predict a worse outcome of MTX ….”
Methotrexate impact on radiographic progression in biologic-treated rheumatoid arthritis under clinical remission: A case report on monozygotic Caucasian twins“776C G influences both neurotoxicity and efficacy of MTX in the Bonn PCNSL protocol.”
“Thymidine, glycine , and adenosine (GAT) prevent methotrexate toxicity only if maintained in the incubation medium.”
“Within 5 min MTX inhibited the incorporation of isotopically-labeled deoxyuridine, hypoxanthine and glycine into DNA, although thymidine incorporation continued normally for more than 90 min before becoming inhibited.”
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