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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Glycine and Methotrexate



Research Papers that Mention the Interaction

Thymidine, glycine , and adenosine (GAT) prevent methotrexate toxicity only if maintained in the incubation medium.
Advances in experimental medicine and biology  •  1983  |  View Paper
Within 5 min MTX inhibited the incorporation of isotopically-labeled deoxyuridine, hypoxanthine and glycine into DNA, although thymidine incorporation continued normally for more than 90 min before becoming inhibited.
European journal of cancer  •  1975  |  View Paper
It has been demonstrated that formate and glycine are effective precursors of ATP adenine and that A-methopterin inhibits the synthesis of this nucleotide.
Cancer research  •  1952  |  View Paper
Furthermore, MTX inhibited formate generation from mitochondria glycine cleavage system (GCS) both in vitro and in vivo.
International journal of molecular sciences  •  2021  |  View Paper