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“There is indeed a host of studies showing that glycine gives rise to many more adverse effects than the same amount of alternative irrigating fluids, such as solutions containing mannitol and/or sorbitol.”
Acta anaesthesiologica Scandinavica • 2006 | View Paper
“Total replacement of Na+ in the incubation medium with mannitol completely suppressed the cellular uptake of glycine , while it reduced glycylglycine uptake only slightly.”
Journal of pharmaceutical sciences • 2003 | View Paper
“Ouabain-induced lethal cell injury results from a process that includes both a volume component ameliorated by mannitol and a volume-independent component that is prevented by glycine and is closely associated with accelerated ATP depletion.”
“The combination of glycine and mannitol completely prevented ouabain-induced lethal injury and cell water increases.”