Possible Interaction: Glycine and Lysine

“Both involve a single-point interchange of glycine and lysine that would result in a difference in charge.”

“In both affected brothers transport of lysine and glycine in vitro was minimally reduced and correlated with modest increases of these amino acids in the urine.”

“However, dissimilar substitutions like threonine and lysine with glycine in the β-hairpin involved in oligomerization, possibly leads to the observed differences in the oligomerization propensity of the two proteins.”

“Accounting for changes in copper speciation, significant inhibition of uptake by glycine and lysine were noted at copper levels of 699 and 1,028 μM. These results suggest that copper–histidine complexes may be transportable via specific amino acid-transporters in the brush-border membrane.”

“ Lysine eliminates all saturable, sodium-independent transport of glycine.”

“Notably, we found that a proline or glycine residue in front of the substrate lysine has a strong adverse effect on the substrate reactivity as compared to a preceding leucine, serine, alanine or arginine residue.”

“Extractions of Asp, Glu, Ser, Asn, Gly , Gln, Tau, His, Cit, Thr, Pro, Tyr, Val, cystine, Ile, Leu, Trp, Orn, and Lys also were correlated with arteriovenous differences of Met.”

“The data indicate an interaction among arginine, lysine and glycine in the nutrition of the chicken, and suggest that the presence of glycine limited the growth depression by lysine in the diet containing the plant proteins.”

“Mutation of the Lys residue to Gly in both FtsY and Ffh NG domains significantly decreased the GTPase activity and GTP binding affinity.”

“The inhibition caused by lysine can be reversed either by glycine , l-isoleucine, l-methionine, or l-phenylalanine.”