Possible Interaction: Glycine and Leucine

“We demonstrate that pairwise replacement of glycines by leucines or isoleucines, but not alanines, in a GXXXG motif led to a drastic reduction of Aβ40 and Aβ42 secretion.”

“In addition, we investigated the possibility that leucine uptake is stimulated by an outwardly directed glycine gradient.”

“Replacement of leucine 43 of YopE with glycine severely affected the delivery of the reporter protein into HeLa cells.”

“Excretion of isovalerylglycine rose threefold when leucine and glycine were administered simultaneously.”

“The K(m) value in millimoles/liter of glycylglycine was significantly greater than the K(m) value …+/-2.6 vs. 26.8+/-5.9, P < 0.05); and the K(m) value of glycine was also significantly …(m) value of leucine (42.7+/-7.5 ….4, P < 0.05).”

“The GLY 3 peak interfered with the resolution of TMS leucine and TMs proline due to the large quantity of glycine in the sample.”

“Gly depletion in plasma can be explained by its trapping by inhibitory action of Leu on the exodus of Gly through transport system L.”

“The insulin effects on K+ balance and [3H]leucine release were … significantly influenced in the presence of glycine (2 mM), although glycine itself inhibited [3H]leucine release by 30.3 +/- 0.3% (n = 4) and 13.8 +/- 1.2% (n = 5) in livers from starved and fed rats, respectively.”

“Coadministration of tyrosine or glycine with leucine negated the leucine effect on ethanol drinking.”

“Triple substitutions of glycine for leucine in positions 2, 5, and 9 or 5, 8, and 9 abolished the uptake of the rat precursor by intact mitochondria, whereas similar alanine substitutions had much less effect.”