Possible Interaction: Glycine and L-4-Chlorokynurenine

“This effect was prevented by 10 μm 7‐chlorokynurenic acid , an antagonist of the glycine site of the NMDA receptor.”

“In addition, 7‐chlorokynurenic acid , an antagonist at the glycine site, is able to reverse the displacement of [3H]CGP 39653 by glycine in a dose‐dependent manner.”

“5 The inhibitory action of 7‐chlorokynurenate and that of CPP on [3H]‐(+)‐MK 801 binding were reversed by addition of glycine and glutamate respectively.”

“An … the glycine site, 7‐chlorokynurenic acid (Cl‐Kyn), completely blocked both the short‐term and the long‐term potentiation associated with theta burst stimulation (TBS) linked to … receptor activation in slices from hippocampus at postnatal days 10–16; this effect was reversed by the glycine agonist, d‐serine.”

“Putative glycine antagonists HA‐966 and 7‐chlorokynurenic acid were highly effective in preventing NMDA neurotoxicity, even in the absence of added glycine.”

“The neuroprotective action of HA‐966 and 7‐chlorokynurenic acid , but not that of NMDA antagonists 3‐(2‐carboxypiperazine‐4‐yl)propylphosphonate and MK‐801, could be reversed by glycine.”

“The glycine antagonist 7‐chlorokynurenic acid inhibited the effects of NMDA and this inhibition was reversed by glycine.”

“Thus, 7-Cl-kyn was approximately 40-fold more potent at the glycine site than at the receptor mediating kainate currents but is probably not entirely competitive at the latter receptor.”