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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
drug:
Isoflurane
Research Papers that Mention the Interaction
“3 For both the recombinant and native receptors, isoflurane potentiated the currents in a dose‐dependent manner at low concentrations of glycine , although at high glycine concentrations the anaesthetic had no significant effect on the glycine‐activated responses.”
Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes“Desflurane, halothane, isoflurane , sevoflurane, and propofol inhibited currents through GLIC at and below concentrations used clinically.”
Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel“RESULTS Intrathecal administration of gl cine pr oduced a significant, dose-dependent decrease in MAC for iso flurane (u p to -65.2% +/- 16.2%).”
“Conclusions:Xenon and isoflurane inhibit NMDA receptors by binding at the same site as the coagonist glycine.”
“The authors show that inhibition of NMDA receptors by xenon and isoflurane increases as glycine concentration is decreased, consistent with the prediction of competitive inhibition at the glycine site.”
“The authors show that xenon and isoflurane compete for the binding of the coagonist glycine on the NMDA receptor NR1 subunit.”
“ Isoflurane reduced glutamate concentrations in both structures and glycine concentrations in the hippocampus.”
“The GLIC pore is predicted to be blocked at the micromolar concentrations for which inhibition by isofluorane and propofol is observed experimentally.”
General Anesthetics Predicted to Block the GLIC Pore with Micromolar Affinity
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