Possible Interaction: Glycine and Insulin

“Together, these results show that insulin has a novel regulatory action on the potency of glycine for ionotropic glycine receptors.”

“Whole-cell patch-clamp recordings showed that insulin reversibly enhanced current evoked by exogenous glycine and increased the amplitude of spontaneous glycinergic miniature inhibitory postsynaptic currents recorded in cultured spinal neurons.”

“Substitution of IleA10 in insulin with glycine reduced the receptor binding ability by 2 orders of magnitude.”

“The oliguria produced by insulin could be counteracted by the injection of glycine , a known precursor of urinary ammonia.”

“In particular, glycine has immunomodulatory properties and is a secretagogue of insulin.”

“Similarly, the long C=O bond length in glycine results in a weakened C=O bond with an enhanced affinity toward cations and the formation of insoluble salts.”

“ Glycine ingestion increases plasma concentrations of insulin in a similar way to other amino acids.1 Glycine is also an inhibitory neurotransmitter.”

“Net negative balances of alanine, methionine, glycine , threonine and asparagine (typical substrates for system A amino acid transport) also were decreased by insulin , whereas serine (another substrate for system A transport) shifted from a zero balance to net uptake.”

“Further analysis suggests that insulin and IGF-I are causing a recruitment of additional glycine transporters at the cell surface or activating otherwise nonfunctional transporters by an unexplained mechanism.”

“The uptake of glycine was increased 25-50% by either insulin or IGF-I. The response to insulin or IGF-I on glycine uptake is gradual and concentration dependent.”

“As expected, the infusion of insulin exhibited significant reduction of the release of glycine , proline, valine, phenylalanine, leucine, threonine and isoleucine.”

“ Insulin upregulated the A system-mediated uptake of glycine in pregnant mouse mammary tissue cultured in vitro, while the (Na++Cl−)-dependent, MeAIB-insensitive system remained unaffected.”