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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glycine
drug:
Ifenprodil
Research Papers that Mention the Interaction
“The glutamate effects were enhanced by glycine application and were prevented by the NMDA receptor blocker MK 801, as well as by the NR2B selective antagonist ifenprodil.”
Expression of functional NR1/NR2B‐type NMDA receptors in neuronally differentiated SK‐N‐SH human cell line“ Ifenprodil at a dose of …,324 (an antagonist at glycine site , 1mg/kg), MK-801 (a non-competitive antagonist, 0.05mg/kg) and d-cycloserine (a partial agonist of a … inorganic modulator of the NMDA receptor complex, such as Zn(2+) (2.5mg/kg) or Mg(2+) (10mg/kg).”
Effects of ifenprodil on the antidepressant-like activity of NMDA ligands in the forced swim test in mice“In older neurons, which contain NMDA receptors with both high and low affinities for glycine, ifenprodil (10 μm) inhibits both the high-affinity population and a significant proportion of the low-affinity component, thus revealing three pharmacologically distinct populations of NMDA receptors in single neurons.”
“However, the inhibitory effect of 1 microM ifenprodil at NR1A/NR2B receptors was reduced by increasing the concentration of glycine.”
“Thus, part of the mechanism of action of ifenprodil at NR1A/NR2B receptors may involve noncompetitive antagonism of the effects of glycine.”
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