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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
supplement:
Homocysteine
Research Papers that Mention the Interaction
“Both peak amplitude and desensitization effects of HCY can be occluded by saturating the NMDAR with glycine.”
Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition.“Although glycine did not affect homocysteine uptake or export, coincubation of homocysteine with glycine for 24h reduced the intracellular concentration of homocysteine.”
“Competition studies revealed that the small neutral amino acids tyrosine, cysteine, glycine , serine, alanine, methionine, and leucine inhibited Hcy uptake in both cell types, but the inhibition was greater for tyrosine, serine, glycine, and alanine in HAECs.”
“Studies with cell-free extracts demonstrated that the glycine cleavage enzyme is inhibited by 45% by L-methionine, L-homocysteine , SAM or SAH.”
“This was supported by the finding that glycine was more potent in combination with HCA than NMDA, in activating NMDA receptors.”
Selectivity of amino acid transmitters acting at N-methyl-D-aspartate and amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors.
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