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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
drug:
Haloperidol
Research Papers that Mention the Interaction
“Further, in controlled clinical trials, GLY and D-Serine enhance the ability of conventional neuroleptics such as haloperidol to improve cognitive and negative symptoms.”
N-methyl-D-aspartate receptor-coupled glycineB receptors in the pathogenesis and treatment of schizophrenia: a critical review.“Objectives We investigated a set of 62 SNPs located in genes coding for subunits of glutamatergic receptors (GAD1, GRIA1, GRIA3, GRIA4, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIN2B, GRM1 and GRM4), and the transporter of glycine (SLC6A5), as modulators of the effects of haloperidol.”
“Interestingly, haloperidol (1 microM), but not clozapine (10 microM), prevented the effects of glycine.”
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics.“Pro and Hyp enhanced also catalepsy, but Gly decreased the haloperidol action.”
“The NMDA receptor antagonist action of haloperidol was neither competitive in nature nor voltage-dependent but was reduced upon elevation of the extracellular concentration of glycine.”
“The effects of glycine were also prevented by either atropine or haloperidol suggesting an involvement of cholinergic and monoaminergic excitatory neurotransmission to the bladder.”
“In animals pretreated with the dopamine receptor blocker, haloperidol , intranigral microinjection of glycine produced a dissociation of the nigral inhibition and caudate excitation.”
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