Possible Interaction: Glycine and Glycylglycine

“Rate of absorption of glycine was significantly higher from the glycylglycine solution (C) than from the glycine solution (A).”

“Five of the six had a higher absorption rate of glycine from the glycylglycine solution.”

“The effect of glycylglycine on absorption of amino acids from the mixture of free amino acids was apparently due to inhibition of amino acid uptake by free glycine liberated from the dipeptide during perfusion.”

“The rates of glycine uptake were always markedly greater from diglycine and triglycine solutions than from corresponding glycine or tetraglycine solutions; rates of glycine uptake from tetraglycine solutions were either similar to or greater than rates from glycine solutions, depending on the infusion concentration.”

“In the Indians the absorption of glycine and glycylglycine was impaired to the same extent, so that the kinetic advantage of glycylglycine as compared with glycine was preserved.”

“Glycine was absorbed faster from a glycyl-glycyl-glycine solution (3·3 mmol/l) than from an equivalent (10 mmol/l) glycine solution, and both l-alanine and glycine were absorbed faster from 10 mmol/l l-alanyl-glycyl-glycine than from the equivalent amino acid mixture.”

“In contrast, in the highest concentration range the competition between glycine and diglycine results in a decrease of absorption.”

“Oxidation of injected glycine (labeling of expired CO2) was significantly enhanced when glycine was given in the form of diglycine but was reduced when given as glycylsarcosine as compared to free-glycine injection.”

“ Glycylglycine , on the other hand, has only a small effect on the accumulation of glycine , although large amounts of the peptide accumulate unchanged in the tissue.”

“Obtaining diglycine HCl by spray drying glycine HCl solutions indicates a 50% loss of HCl during processing.”