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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glycine
supplement:
Glutamic Acid
Research Papers that Mention the Interaction
“Substitution of the glycine at position 468 with an alanine or glutamic acid severely compromises protein activity and stability.”
Identification of a novel motif in DNA ligases exemplified by DNA ligase IV.“The glutamine-to-glutamic acid ratio and glycine were inversely correlated (i.e., LH > MHO > MUO) with HbA1c values.”
“In contrast, substitution of Gly with Glu or β-Ala resulted in only a partial loss of stimulatory activity.”
“At 0.4m-carbodi-imide reagent all of the binding of Ca(2+) to protein was abolished and it was estimated that about 37% of the side-chain carboxyl groups of aspartic acid plus glutamic acid had been blocked by glycine.”
“The responses to Glu , NMDA, and Asp were each potentiated when 1 microM glycine was coapplied.”
Excitatory amino acid receptors on isolated retinal ganglion cells from the goldfish.“Microinjection of Gly 1 -2 min before microinjection of Glu in 7 sites reduced significantly (P less than 0.05) the decrease in HR elicited by Glu from 87.0 +/- 27.3 bpm to 17.7 +/- 7.2 bpm.”
“The addition of a combination of glycine and glutamic acid , urea, or a mixture of NEAA significantly improved growth, but diammonium citrate or other NEAA added singly did not give a significant response.”
“Their normal function requires a simultaneous involvement of glutamic acid (as an agonist) and glycine (as a coagonist).”
Molecular Modeling of the Ligand-Binding Domains of the NR3A and NR3B Subunits of the NMDA Receptor“Substitution of glycine with glutamic acid at position 48 of the human immunodeficiency virus protease resulted in an enzyme with reduced activity on one of the protease processing sites in the viral Pol polyprotein precursor.”
“In addition it has been shown that site specific mutagenesis resulting in the substitution of Gly with Glu leads to a loss of viral infectivity.”
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