Possible Interaction: Glycine and Glutamate

“We showed that the endogenous level of glycine (about 3 mM) was significantly higher than for other candidates such as L-glutamate , L-aspartate, or gamma-aminobutyric acid.”

“Additionally, the body burden of neurotransmitter such as glycine and L-glutamate may concurrently stimulate the swimming behavior.”

“ Glycine protected the A714C mutant from modification by dithionitrobenzoate, whereas the co-agonist L-glutamate was ineffective.”

“ L-glutamate or N-methyl-D-aspartate (NMDA), in combination with glycine , resulted in a rapidly rising current which decayed in the continued presence of agonist.”

“10 nmol (+29 +/- 5 mmHg and -110 +/- 18 bpm), 25 nmol (+12 +/- 7 mmHg and -… +/- 2 mmHg and -100 +/- 31 bpm)] The dose-dependent blockade of the pressor response to L-glutamate … glycine suggests an inhibitory neuromodulatory role for this amino … produced by L-glutamate microinjection into the NTS.”

“First, SPD, like glycine , increases the percentage of time that NMDA channels remain in the open state in the presence of L-glutamate , consistent with a role as a positive allosteric modulator of NMDA receptor activation.”

“Moreover, the effect of L-glutamate on noradrenaline release was significantly potentiated by glycine.”

“Activation of the NMDA subtype of ionotropic glutamate receptors requires binding of both L-glutamate and the coagonist glycine.”

“In the presence of both L-glutamate and glycine , [3H]MK-801 binding in PCP-treated rats increased significantly compared to baseline but did not differ from saline-treated controls.”

“Binding was potentiated by L-glutamate and glycine with EC50 values of around 80 nM. In the presence of L-glutamate (10 microM), specific binding was increased 4-fold, whilst addition of glycine (10 microM) increased specific binding 2-fold.”