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Possible Interaction: Glycine and Felbamate

supplement:

Glycine

Research Papers that Mention the Interaction

Felbamate produced a rapid, concentration-dependent block … 50 microM NMDA and 10 microM glycine in human embryonic kidney 293 cells expressing the rat NR1a subunit, and either the NR2A, NR2B or NR2C … values for block were 2.6, 0.52 and 2.4 mM, respectively (holding potential, - 60 mV).
Epilepsy Research  •  2000  |  View Paper
NMDA antagonists (i.e. MK801 or AP5) prevent the development of epileptic seizures induced by kindling; CNQX, an AMPA antagonist, blocks the increase in electrical activity induced by K+ in slices of hypocampus; felbamate , an antiepileptic drug, blocks the glycine site (not strychnine sensitive) decreasing NMDA receptor activity.
Medicina  •  1995  |  View Paper
Felbamate decreased the magnitude of glycine (100 microM)-enhanced NMDA (100 microM)-induced intracellular calcium ([Ca2+]i) transients in mouse cerebellar granule cells which had been loaded with the Ca(2+)-sensitive fluorescent probe indo-1 acetoxymethyl ester (indo-1/AM).
Epilepsy Research  •  1995  |  View Paper
Pretreatment with glycine , an agonist to the glycine/NMDA receptors, shifted the dose-response effect of felbamate to the right (ED50 = 56.8 against tonus and 94.8 mg/kg versus clonus).
European journal of pharmacology  •  1994  |  View Paper
Glycine blocked the anticonvulsant effects of felbamate on electroshock- and NMDA-induced seizures in mice.
European journal of pharmacology  •  1994  |  View Paper
However, the addition of 10 microM glycine with felbamate during hypoxia, reduced this recovery to 16 +/- 12%.
Neuroreport  •  1993  |  View Paper