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Environmental health perspectives • 2009 | View Paper
“Our observations suggest that glycine is a multifaceted regulator of d-serine metabolism and implicate both d-serine and glycine in mediating NMDAR synaptic activation at the mature hippocampus through a Phgdh-dependent shuttle mechanism.”
“Unexpectedly, we also discovered that glycine regulates d-serine metabolism by a dual mechanism.”
“We show that glycine is a significant regulator of d-serine synthesis and release, revealing a cross-talk between glycine and d-serine metabolism that fine tunes NMDAR activation.”
Pharmacology Biochemistry and Behavior • 2012 | View Paper
“ D-serine modestly decreased levels of glycine , which were enhanced by administration of glycine itself and of the glycine transporter-1 inhibitor, sarcosine.”
Journal of Neuroscience Methods • 2011 | View Paper
“Furthermore, in vivo microdialysis demonstrated that intraperitoneal injection of glycine significantly increased glycine and l-serine levels, but decreased d-serine levels in the prefrontal cortex.”