Possible Interaction: Glycine and D-Serine

“ d-Serine and glycine are coagonists of NMDA receptors (NMDARs), but their relative contributions for several NMDAR-dependent processes are unclear.”

“Contrasting evidence has been reported for glycine and D-serine , that may however have a role as add-on agents.”

“Co-administration of d-serine and glycine also inhibited the PCP-induced decrease in neurogenesis.”

“Our observations suggest that glycine is a multifaceted regulator of d-serine metabolism and implicate both d-serine and glycine in mediating NMDAR synaptic activation at the mature hippocampus through a Phgdh-dependent shuttle mechanism.”

“Unexpectedly, we also discovered that glycine regulates d-serine metabolism by a dual mechanism.”

“We show that glycine is a significant regulator of d-serine synthesis and release, revealing a cross-talk between glycine and d-serine metabolism that fine tunes NMDAR activation.”

“Glutamate is an NMDA receptor agonist, and glycine and D-serine act as co-agonists.”

“ D-serine modestly decreased levels of glycine , which were enhanced by administration of glycine itself and of the glycine transporter-1 inhibitor, sarcosine.”

“Furthermore, in vivo microdialysis demonstrated that intraperitoneal injection of glycine significantly increased glycine and l-serine levels, but decreased d-serine levels in the prefrontal cortex.”

“Furthermore, co-administration of D-serine and glycine , but not L-serine, inhibited the PCP-induced decrease in the number of BrdU-labeled cells.”

“Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation.”

“Systemically administered glycine and D-serine were found to decrease MK-801-induced hyperactivity.”