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Last Updated: 2 years ago

Possible Interaction: Glycine and D-Serine

supplement:

Glycine

supplement:

D-Serine

Research Papers that Mention the Interaction

d-Serine and glycine are coagonists of NMDA receptors (NMDARs), but their relative contributions for several NMDAR-dependent processes are unclear.
The Journal of Neuroscience  •  2013  |  View Paper
Contrasting evidence has been reported for glycine and D-serine , that may however have a role as add-on agents.
European journal of pharmacology  •  2012  |  View Paper
Co-administration of d-serine and glycine also inhibited the PCP-induced decrease in neurogenesis.
Environmental health perspectives  •  2009  |  View Paper
Our observations suggest that glycine is a multifaceted regulator of d-serine metabolism and implicate both d-serine and glycine in mediating NMDAR synaptic activation at the mature hippocampus through a Phgdh-dependent shuttle mechanism.
Unexpectedly, we also discovered that glycine regulates d-serine metabolism by a dual mechanism.
We show that glycine is a significant regulator of d-serine synthesis and release, revealing a cross-talk between glycine and d-serine metabolism that fine tunes NMDAR activation.
Proceedings of the National Academy of Sciences  •  2019  |  View Paper
Glutamate is an NMDA receptor agonist, and glycine and D-serine act as co-agonists.
Pharmacology Biochemistry and Behavior  •  2012  |  View Paper
D-serine modestly decreased levels of glycine , which were enhanced by administration of glycine itself and of the glycine transporter-1 inhibitor, sarcosine.
Journal of Neuroscience Methods  •  2011  |  View Paper
Furthermore, in vivo microdialysis demonstrated that intraperitoneal injection of glycine significantly increased glycine and l-serine levels, but decreased d-serine levels in the prefrontal cortex.
Psychopharmacology  •  2008  |  View Paper
Furthermore, co-administration of D-serine and glycine , but not L-serine, inhibited the PCP-induced decrease in the number of BrdU-labeled cells.
Journal of pharmacological sciences  •  2007  |  View Paper
Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation.
Journal of Neural Transmission / General Section JNT  •  2006  |  View Paper
Systemically administered glycine and D-serine were found to decrease MK-801-induced hyperactivity.
Journal of Neural Transmission  •  2005  |  View Paper
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