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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glycine
drug:
Benzoic Acid
Research Papers that Mention the Interaction
“ Benzoic acid binds to glycine to form hippurate, which is subsequently eliminated through the kidneys.”
Determination of benzoic acid in serum or plasma by gas chromatography-mass spectrometry (GC/MS).“ Benzoic acid , by conjugation with glycine to form hippuric acid, is known to deplete the free glycine pool of the body.”
“Apparently, the inhibitory effect of benzoic acid on the formation of salicyluric acid is not due to competition for glycine but involves another phase in the biotransformation process.”
“The major route of biotransformation of benzoic acid and salicylic acid in man is conjugation with glycine , resulting in the formation of hippuric acid and salicyluric acid, respectively.”
“The rate of hippuric acid formation after oral administration of 5 g. benzoic acid in solution is increased markedly by the concomitant administration of glycine.”
“LA inhibited glycine conjugation of benzoic acid in a dose-dependent manner as indicated by: 1) reduced clearance of benzoic acid from blood; 2) delayed appearance of benzoylglycine in blood; and 3) decreased excretion of benzoylglycine in urine.”
Lipoic acid impairs glycine conjugation of benzoic acid and renal excretion of benzoylglycine.“ Benzoic acid was further conjugated with glycine to produce hippuric acid.”
“ Glycine prevented the inhibition of fatty acid synthesis caused by benzoic acid , but had no effect on that caused by p-tert.”
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