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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Glycine
drug:
Antipsychotic Agents
Research Papers that Mention the Interaction
“In a previous study, significant improvements in negative and cognitive symptoms were observed in a group of 21 schizophrenic patients receiving high-dose glycine in addition to antipsychotic treatment.”
Adjunctive high-dose glycine in the treatment of schizophrenia.“CONCLUSIONS These preliminary data suggest that gl cine ma y interfere with the antipsychotic efficacy of aty pical neuroleptics su ch as clozapine.”
“Several studies have tested the effects of combining glycine with certain antipsychotics or using glycine transport inhibitors with promising results.”
“Of these, the full agonists glycine and D-serine have both shown to induce significant, large effect size reductions in persistent negative and cognitive symptoms when added to traditional or newer atypical antipsychotics in double-blind, placebo-controlled clinical studies.”
“Further, in controlled clinical trials, GLY and D-Serine enhance the ability of conventional neuroleptics such as haloperidol to improve cognitive and negative symptoms.”
“Available data suggest that antipsychotic drugs may restore balance among kynurenine pathway metabolites, and that co-administration of glycine with antipsychotics may reduce extrapyramidal symptoms in patients suffering from schizophrenia.”
“Early clinical trials conducted at single sites found that glycine administered in combination with antipsychotics could reduce negative and cognitive symptoms when compared with antipsychotics alone (Javitt et al. 1994; HerescoLevy et al. 1996, 1999, 2004).”
“This article proposes a polypharmacy of glycine site potentiators augmented with antipsychotic drugs to control positive and negative symptoms in a synergistic manner and block deterioration in schizophrenia.”
“ Glycine and D-serine may somewhat improve negative symptoms when added to regular antipsychotic medication , but the results were not fully consistent and data are too few to allow any firm conclusions.”
“In all of these trials, glycine , D-serine, D-cycloserine, or ampakine CX516 was used to augment the effect of antipsychotic drugs.”
“Following a prolonged preincubation wash, APDs resulted in a reduction in both unenhanced binding and glycine enhanced binding.”
Chronic antipsychotic treatment alters glycine-stimulated NMDA receptor binding in rat brain
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