Possible Interaction: Glycine and Anesthetics, Inhalation

“More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as γ-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of inhaled anaesthetics.”

“2 Inhalational general anaesthetics , at concentrations close to their human minimum alveolar concentrations (MACs), potentiated responses to low concentrations of glycine.”

“It was not surprising to find that urethane, like most IV and inhaled anesthetics , enhanced the currents of inhibitory receptors (GABAA, glycine ) and inhibited current responses of excitatory receptors (NMDA, AMPA) in a dose-dependent manner (10).”