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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Glycine
drug:
Amprenavir
Research Papers that Mention the Interaction
“These effects were potentiated by glycine and blocked by extracellular Mg2+, 2-amino-5-phosphonopentanoate ( APV ), 7-chlorokynurenate, 3-amino-1-hydroxypyrrolidin-2-one (HA-966) and 5,7-dinitroquinoxaline-2,3-dione (MNQX).”
Endogenous γ-l-glutamylglutamate is a partial agonist at the N-methyl-d-aspartate receptors in cultured cerebellar granule cells“ Glycine enhanced this block, while APV attenuated it.”
“The antinociceptive activity of APV was significantly enhanced by combination with a non‐analgesic dose of the allosteric‐glycine agonist glycine , and was reduced by combination with the allosteric‐glycine antagonist 7‐CKA which also reversed the glycine‐induced enhancement of the antinociceptive effects of APV.”
“However, those activated by L-glutamate plus glycine still appeared in the presence of APV in about 18% of the cases, but with lower conductance levels.”
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