Possible Interaction: Glycerol and Urea

“Equilibration of creatinine and urea was slower and creatinine clearance lower with glycerol.”

“At -20°C, added urea (0.2-1.0 mol/L) caused a rapid decrease in hCG immunoreactivity, which glycerol (5-10%) prevented.”

“RESULTS Gl cerol ad ministration resulted in an increase in the mean histologic damage score, serum Cr, ure a an d CK, kidney tissue ROS, malondialdehyde, 8-OH-dG, GSH-PX, IL-6, and TNF-α, and a decrease in kidney tissue superoxide dismutase activity.”

“Results: The isosmotic addition of glycerol and urea resulted in depolarization of the plasma membrane and electrical activity, accompanied by β-cell swelling, activation of the volume-regulated anion channel (VRAC) and insulin release.”

“However, in the present study using a closed loop of rat small intestine in situ, we found that the absorption of glycerol was faster than that of urea , a probe solute widely assumed to permeate exclusively via the paracellular route.”

“A marked increase in plasma urea concentration was found after the glycerol injection.”

“Moreover, urea could decrease the synthesis of glycerol from glucose by 26% comparing with ammonium.”

“In addition, it was observed that the interactive effect between crude glycerol and urea was statistically significant.”

“ Urea and glycerol inhibit self-association, and arginine shows a dual nature.”

“The formation of glycerophosphates occurs when glycerol is heated with ammonium dihydrogen phosphate and either urea or cyanamide.”